CHzCON NCHzCHzOH u tiaramide hydrochloride nonacidic antiinflammatory agent which inhibits acute inflammati~ n'~~ and the release of histamine and TXAz without affecting the cyclo-oxygenase system. 14b From the results listed in Tables I and 11, the following structureactivity relationships can be deduced. The parent compound is almost inactive; however, introduction of a lipophilic substituent at the 6 position of
