Il Farmaco

Synthesis and μ-opioid receptor affinity of a new series of nitro substituted 3, 8-diazabicyclo [3.2. 1] octane derivatives

D Barlocco, G Cignarella, P Vianello, S Villa, GA Pinna…

文献索引：Barlocco; Cignarella; Vianello; Villa; Pinna; Fadda; Fratta Farmaco, 1998 , vol. 53, # 8-9 p. 557 - 562

全文：HTML全文

被引用次数: 10

摘要

A new series of analogues (1c–j; 2c–i) of the previously reported analgesic 3, 8-diazabicyclo [3.2. l] octanes (1a, b; 2a, b) was synthesized and tested for their affinity towards μ-opioid receptors. Modifications were introduced either at the cinnamyl or the acyl side chains. The majority of the new compounds, with the exception of 1c, j and 2c, showed Ki values better or comparable with those of the models.