Evaluation of isomeric 4-(chlorohydroxyphenyl)-1, 2, 3, 4-tetrahydroisoquinolines as dopamine D-1 antagonists

RM Riggs, DE Nichols, MM Foreman…

文献索引：Riggs; Nichols; Foreman; Truex Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1887 - 1891

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被引用次数: 22

摘要

The isomeric 4-(3-chloro-4-hydroxyphenyl)-and 4-(4-chloro-3-hydroxyphenyl)-1, 2, 3, 4- tetrahydroisoquinolines, the N-methyl derivative of the 4-(4-chloro-3-hydroxyphenyl) isomer, and 4-(3-hydroxyphenyl)-l, 2, 3, 4-tetrahydroisoquinoline were synthesized and evaluated for dopamine D-1 antagonist activity. The 4-(3-chloro-4-hydroxyphenyl) and the 4-(3- hydroxyphenyl) isomer possessed similar potencies as D-1 antagonists. Introduction of ...