Synthesis and central nervous system properties of 2-[(alkoxycarbonyl) amino]-4 (5)-phenyl-2-imidazolines

K Weinhardt, CC Beard, C Dvorak, M Marx…

文献索引：Weinhardt; Beard; Dvorak; Marx; Patterson; Roszkowski; Schuler; Unger; Wagner; Wallach Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 616 - 627

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被引用次数: 15

摘要

A series of 2-[(alkoxycarbonyl) amino]-4 (5)-phenyl-2-imidazolines was prepared and evaluated for central nervous system (CNS) effects (antidepressant, anticonvulsant, muscle relaxant, and depressant) in animal models. Some separation of those CNS activities was achieved through substitutions on the phenyl and imidazoline moieties. Halo-substituted phenyl compounds were among the most potent antidepressants in this series, while ...