Initiation of DNA strand cleavage by 1, 2, 4-benzotriazine 1, 4-dioxide antitumor agents: mechanistic insight from studies of 3-methyl-1, 2, 4-benzotriazine 1, 4-dioxide
... Volume: Page: ... The dehydration process proposed for the formation of 4 finds some general precedent in radiation chemistry (Scheme 4). In ... drugs may be facilitated by improved understanding of the molecular mechanisms by which this new chemical class of ...