Chemical Communications

Synthesis and incorporation of carbocyclic nucleosides into a hammerhead ribozyme domain–RNase resistance and catalytic activity

F Burlina, A Favre, JL Fourrey, M Thomas

文献索引：Burlina, Fabienne; Favre, Alain; Fourrey, Jean-Louis; Thomas, Martial Chemical Communications, 1996 , # 14 p. 1623 - 1624

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被引用次数: 1

摘要

RNA enzymes or ribozymes are endonucleases which cleave, in a sequence dependent manner, their RNA substrates.l Among natural ribozymes, the hammerhead motif, as found in the self- cleaving domain of plus-strand satellite RNA from tobacco ringspot virus,2 has served to engineer trans acting ribozymes.3 Because of its simplicity the hammerhead system has received a great deal of atttention focusing at the elucidation of its three dimensional structure,4 the ...