Efficient Synthesis of Pyrazoles: Oxidative C C/N N Bond??Formation Cascade

JJ Neumann, M Suri, F Glorius

文献索引：Neumann, Julia J.; Suri, Mamta; Glorius, Frank Angewandte Chemie - International Edition, 2010 , vol. 49, # 42 p. 7790 - 7794

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被引用次数: 118

摘要

Although pyrazoles are rarely found in natural products, they represent an important motif of manmade biologically active compounds like the anti-inflammatory drug Celecoxib and the insecticide Fipronil.[1] Arguably, the most popular methods for the preparation of 1, 3, 4, 5- tetrasubstituted pyrazoles are the dipolar [3+ 2] cycloaddition between a CN2 and a C2 moiety or the classical cyclocondensation of a monosubstituted hydrazine with a 1, 3- ...