Synthesis and quantitative structure-activity relationship analysis of N-triiodoallyl-and N-iodopropargylazoles. New antifungal agents

M Koyama, N Ohtani, F Kai, I Moriguchi…

文献索引：Koyama; Ohtani; Kai; Moriguchi; Inouye Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 552 - 562

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被引用次数: 55

摘要

New series of N-(2, 3, 3-triiodoallyl) and N-(3-iodopropargyl) azole derivatives (100 compounds) involving pyrrole, pyrazole, imidazole, triazole, and tetrazole nuclei were synthesized successively with the aid of quantitative structure-activity relationship (QSAR) analysis to obtain potent antifungal agents. Starting from the derivatives of nitropyrrole- containing antibiotics, the QSAR analysis of the pyrrole derivatives against Candida ...