Palladium-Catalyzed Enantioselective α-Arylation of α-Fluoroketones

Z Jiao, JJ Beiger, Y Jin, S Ge, J Zhou…

文献索引：Guo, Yong; Twamley, Brendan; Shreeve, Jean'Ne M. Organic and Biomolecular Chemistry, 2009 , vol. 7, # 8 p. 1716 - 1722

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摘要

... jacs.6b09580. Publication Date (Web): November 4, 2016. Copyright © 2016 American Chemical Society. ... α-Aryl carbonyl compounds are widespread in medicinal chemistry and are often employed in ... to form secondary(6) but not tertiary α-fluoro stereogenic centers,(7) or they ...

~16%

~12%

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~50%

详细

. alpha.-Fluorination of carbonyl compounds with trifluorome...

[Middleton, W. J.; Bingham, E. M. Journal of the American Chemical Society, 1980 , vol. 102, # 14 p. 4845 - 4846]

New Methodology for the Synthesis of α, α-difluoroketones

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Oxidations with Oxygen Difluoride. II. Addition to Unsaturat...

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Gold??Catalyzed Synthesis of α??Fluoro Acetals and α??Fluoro...

[De Haro, Teresa; Nevado, Cristina Advanced Synthesis and Catalysis, 2010 , vol. 352, # 16 p. 2767 - 2772]