The Journal of Organic Chemistry

Synthesis of the bacterial coenzyme methoxatin

JA Gainor, SM Weinreb

文献索引：Gainor, James A.; Weinreb, Steven M. Journal of Organic Chemistry, 1982 , vol. 47, # 15 p. 2833 - 2837

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被引用次数: 42

摘要

(73%). 15 Without purification, 7 was heated with polyphosphoric acid at 100 “C to give orange isatin 8 (70%). A potentially more efficient route for conversion of 4 to 8 was investigated at this point. Isocyanate 11, which is an intermediate in the conversion of acid 4 to aniline 6, was easily isolated and was treated with potassium cyanide to afford acyl nitrile 12 (eq 2). However, exposure of 12 11 cH3)/4-, N1N