Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties

MA Seleem, AM Disouky, H Mohammad…

文献索引：Mohammad, Haroon; Mayhoub, Abdelrahman S.; Ghafoor, Adil; Soofi, Muhammad; Alajlouni, Ruba A.; Cushman, Mark; Seleem, Mohamed N. Journal of Medicinal Chemistry, 2014 , vol. 57, # 4 p. 1609 - 1615

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被引用次数: 3

摘要

A series of second-generation analogues for 2-(1-(2-(4-butylphenyl)-4-methylthiazol-5-yl) ethylidene) aminoguanidine (1) have been synthesized and tested against methicillin- resistant Staphylococcus aureus (MRSA). The compounds were designed with the objective of improving pharmacokinetic properties. This main aim has been accomplished by replacing the rapidly hydrolyzable Schiff-base moiety of first-generation members with a ...