Synlett

Iron-catalyzed inexpensive and practical synthesis of N-substituted pyrroles in water

N Azizi, A Khajeh-Amiri, H Ghafuri, M Bolourtchian…

文献索引：Azizi, Najmedin; Khajeh-Amiri, Alireza; Ghafuri, Hossein; Bolourtchian, Mohammad; Saidi, Mohammad Reza Synlett, 2009 , # 14 p. 2245 - 2248

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被引用次数: 45

摘要

Abstract An operationally simple, practical, and economical protocol for iron (III) chloride catalyzed Paal-Knorr pyrrole synthesis in water in good to excellent yields has been developed. Several N-substituted pyrroles are readily prepared from the reaction of 2, 5- dimethoxytetrahydrofuran and aryl/alkyl, sulfonyl and acyl amines under very mild reaction conditions