Synthetic enterobactin analogs. Carboxamido-2, 3-dihydroxyterephthalate conjugates of spermine and spermidine

FL Weitl, KN Raymond, PW Durbin

文献索引：Weitl, Frederick L.; Raymond, Kenneth N.; Durbin, Patricia W. Journal of Medicinal Chemistry, 1981 , vol. 24, # 2 p. 203 - 206

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被引用次数: 52

摘要

Since all the ligands were as conformationally flexible as thyroxine, I can not claim to have determined the relative orientation of the two aromatic rings for the ligand as it lies in the site. In general, if the data set is limited in range of binding energies, conformational differences, and chemical structural differences, then necessarily the outcome of this method must be a limited picture of the site.