Synthesis and anticonvulsant evaluation of some new 2-substituted-3-arylpyrido [2, 3-d] pyrimidinones

…, TD Greenwood, AL Downey, JR Bloomquist…

文献索引：White, David C.; Greenwood, Thomas D.; Downey, Aaron L.; Bloomquist, Jeffrey R.; Wolfe, James F. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 21 p. 5711 - 5717

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被引用次数: 26

摘要

A series of 2-substituted-3-arylpyrido [2, 3-d] pyrimidinones was prepared for evaluation as potential anticonvulsants. In murine screening, compounds 4a–c having a 2-oxo-2-(4- pyridyl) ethyl group in the 2-position and a 2-substituted phenyl moiety at the 3-position of the pyridopyrimidinone system displayed the most potent anti-seizure activity in both the maximal electroshock (MES) and pentylenetetrazol (scPTZ) tests at doses in the 3–10mg/ ...