Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y4 receptor
H Maruoka, MPS Jayasekara, MO Barrett…
文献索引：Maruoka, Hiroshi; Jayasekara, M. P. Suresh; Barrett, Matthew O.; Franklin, Derek A.; De Castro, Sonia; Kim, Nathaniel; Costanzi, Stefano; Harden, T. Kendall; Jacobson, Kenneth A. Journal of Medicinal Chemistry, 2011 , vol. 54, # 12 p. 4018 - 4033
P2Y2 and P2Y4 receptors are G protein-coupled receptors, activated by UTP and dinucleoside tetraphosphates, which are difficult to distinguish pharmacologically for lack of potent and selective ligands. We structurally varied phosphate and uracil moieties in analogues of pyrimidine nucleoside 5′-triphosphates and 5′-tetraphosphate esters. P2Y4 receptor potency in phospholipase C stimulation in transfected 1321N1 human ...
