Structural Features Important for. sigma. 1 Receptor Binding

…, AM Ismaiel, MB El-Ashmawy, JB Fischer…

文献索引：Glennon; Ablordeppey; Ismaiel; El-Ashmawy; Fischer; Howie Journal of Medicinal Chemistry, 1994 , vol. 37, # 8 p. 1214 - 1219

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被引用次数: 112

摘要

Two problems that have hampered u receptor research are (i) a lack of high-affinity agents and (ii) the recent identification of multiple populations of u receptors (ie, u1 and 6 2 sites). Recently, several high-affinity u ligands have been identified, and the term superpotent u ligands has been coined to describe agents with Ki values of< 1 nM. We have previously shown that appropriately N-substituted phenylalkylamines bind at u receptors with high ...