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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis and CNS Activity of N, N??Disubstituted 1??(Aminomethyl)??5??alkyl??3??(aryloxyacetylhydrazono) indolin??2??ones

R Agarwal, S Misra, RK Satsangi…

文献索引：Agarwal; Misra; Satsangi; Tiwari Archiv der Pharmazie, 1982 , vol. 315, # 2 p. 142 - 146

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被引用次数: 5

摘要

Abstract Isatin and 5-methylisatin were condensed with various aryloxyacetylhydrazides to furnish the 3-(aryloxyacetylhydrazono)-5-alkylindolin-2-ones 1–4. When 1–4 were subjected to Mannich reaction, the N, N-disubstituted 1-(aminomethyl)-5-alkyl-3-( aryloxyacetylhydrazono) indolin-2-ones 5–8 were obtained. The compounds were CNS active and relatively non-toxic (albino mice).

甲醛结构式

甲基苯基哌嗪结构式

甲基苯基哌嗪

3-(2-Naphthyloxyacetylhydrazono)-indolin-2-one结构式

3-(2-Naphthylox...

~65%

N-[(E)-[1-[[4-(4-methylphenyl)piperazin-1-yl]methyl]-2-oxoindol-3-ylidene]amino]-2-naphthalen-2-yloxyacetamide结构式

N-[(E)-[1-[[4-(...

2-(2-萘氧基)乙酰肼结构式

2-(2-萘氧基)乙酰肼

~%

N-[(E)-[1-[[4-(4-methylphenyl)piperazin-1-yl]methyl]-2-oxoindol-3-ylidene]amino]-2-naphthalen-2-yloxyacetamide结构式

N-[(E)-[1-[[4-(...

靛红结构式

~%

N-[(E)-[1-[[4-(4-methylphenyl)piperazin-1-yl]methyl]-2-oxoindol-3-ylidene]amino]-2-naphthalen-2-yloxyacetamide结构式

N-[(E)-[1-[[4-(...

四氢吡咯结构式

甲醛结构式

[2]naphthyloxy-acetic acid-(5-methyl-2-oxo-indolin-3-ylidenehydrazide)结构式

[2]naphthyloxy-...

~65%

N-[[5-methyl-2-oxo-1-(pyrrolidin-1-ylmethyl)indol-3-ylidene]amino]-2-naphthalen-2-yloxyacetamide结构式

N-[[5-methyl-2-...

5-甲基靛红结构式

~%

N-[[5-methyl-2-oxo-1-(pyrrolidin-1-ylmethyl)indol-3-ylidene]amino]-2-naphthalen-2-yloxyacetamide结构式

N-[[5-methyl-2-...

2-(2-萘氧基)乙酰肼结构式

2-(2-萘氧基)乙酰肼

~%

N-[[5-methyl-2-oxo-1-(pyrrolidin-1-ylmethyl)indol-3-ylidene]amino]-2-naphthalen-2-yloxyacetamide结构式

N-[[5-methyl-2-...

吗啉结构式

甲醛结构式

[2]naphthyloxy-acetic acid-(5-methyl-2-oxo-indolin-3-ylidenehydrazide)结构式

[2]naphthyloxy-...

~68%

N-[[5-methyl-1-(morpholin-4-ylmethyl)-2-oxoindol-3-ylidene]amino]-2-naphthalen-2-yloxyacetamide结构式

N-[[5-methyl-1-...

5-甲基靛红结构式

~%

N-[[5-methyl-1-(morpholin-4-ylmethyl)-2-oxoindol-3-ylidene]amino]-2-naphthalen-2-yloxyacetamide结构式

N-[[5-methyl-1-...

2-(2-萘氧基)乙酰肼结构式

2-(2-萘氧基)乙酰肼

~%

N-[[5-methyl-1-(morpholin-4-ylmethyl)-2-oxoindol-3-ylidene]amino]-2-naphthalen-2-yloxyacetamide结构式

N-[[5-methyl-1-...

六氢吡啶结构式

甲醛结构式

[2]naphthyloxy-acetic acid-(5-methyl-2-oxo-indolin-3-ylidenehydrazide)结构式

[2]naphthyloxy-...

~72%

N-[(E)-[5-methyl-2-oxo-1-(piperidin-1-ylmethyl)indol-3-ylidene]amino]-2-naphthalen-2-yloxyacetamide结构式

N-[(E)-[5-methy...

5-甲基靛红结构式

~%

N-[(E)-[5-methyl-2-oxo-1-(piperidin-1-ylmethyl)indol-3-ylidene]amino]-2-naphthalen-2-yloxyacetamide结构式

N-[(E)-[5-methy...

2-(2-萘氧基)乙酰肼结构式

2-(2-萘氧基)乙酰肼

~%

N-[(E)-[5-methyl-2-oxo-1-(piperidin-1-ylmethyl)indol-3-ylidene]amino]-2-naphthalen-2-yloxyacetamide结构式

N-[(E)-[5-methy...

六氢吡啶结构式

甲醛结构式

3-(2-Naphthyloxyacetylhydrazono)-indolin-2-one结构式

3-(2-Naphthylox...

~69%

2-naphthalen-2-yloxy-N-[(E)-[2-oxo-1-(piperidin-1-ylmethyl)indol-3-ylidene]amino]acetamide结构式

2-naphthalen-2-...

2-(2-萘氧基)乙酰肼结构式

2-(2-萘氧基)乙酰肼

~%

2-naphthalen-2-yloxy-N-[(E)-[2-oxo-1-(piperidin-1-ylmethyl)indol-3-ylidene]amino]acetamide结构式

2-naphthalen-2-...

靛红结构式

~%

2-naphthalen-2-yloxy-N-[(E)-[2-oxo-1-(piperidin-1-ylmethyl)indol-3-ylidene]amino]acetamide结构式

2-naphthalen-2-...

甲醛结构式

甲基苯基哌嗪结构式

甲基苯基哌嗪

[2]naphthyloxy-acetic acid-(5-methyl-2-oxo-indolin-3-ylidenehydrazide)结构式

[2]naphthyloxy-...

~72%

N-[(E)-[5-methyl-1-[[4-(4-methylphenyl)piperazin-1-yl]methyl]-2-oxoindol-3-ylidene]amino]-2-naphthalen-2-yloxyacetamide结构式

N-[(E)-[5-methy...

5-甲基靛红结构式

~%

N-[(E)-[5-methyl-1-[[4-(4-methylphenyl)piperazin-1-yl]methyl]-2-oxoindol-3-ylidene]amino]-2-naphthalen-2-yloxyacetamide结构式

N-[(E)-[5-methy...

2-(2-萘氧基)乙酰肼结构式

2-(2-萘氧基)乙酰肼

~%

N-[(E)-[5-methyl-1-[[4-(4-methylphenyl)piperazin-1-yl]methyl]-2-oxoindol-3-ylidene]amino]-2-naphthalen-2-yloxyacetamide结构式

N-[(E)-[5-methy...

吗啉结构式

甲醛结构式

未登录结构式

~82%

N-[[1-(morpholin-4-ylmethyl)-2-oxoindol-3-ylidene]amino]-2-(4-nitrophenoxy)acetamide结构式

N-[[1-(morpholi...

4-硝基苯氧基乙酸肼结构式

4-硝基苯氧基乙酸肼

~%

N-[[1-(morpholin-4-ylmethyl)-2-oxoindol-3-ylidene]amino]-2-(4-nitrophenoxy)acetamide结构式

N-[[1-(morpholi...

靛红结构式

~%

N-[[1-(morpholin-4-ylmethyl)-2-oxoindol-3-ylidene]amino]-2-(4-nitrophenoxy)acetamide结构式

N-[[1-(morpholi...

甲醛结构式

甲基苯基哌嗪结构式

甲基苯基哌嗪

未登录结构式

~67%

N-[(E)-[1-[[4-(4-methylphenyl)piperazin-1-yl]methyl]-2-oxoindol-3-ylidene]amino]-2-(4-nitrophenoxy)acetamide结构式

N-[(E)-[1-[[4-(...

4-硝基苯氧基乙酸肼结构式

4-硝基苯氧基乙酸肼

~%

N-[(E)-[1-[[4-(4-methylphenyl)piperazin-1-yl]methyl]-2-oxoindol-3-ylidene]amino]-2-(4-nitrophenoxy)acetamide结构式

N-[(E)-[1-[[4-(...

靛红结构式

~%

N-[(E)-[1-[[4-(4-methylphenyl)piperazin-1-yl]methyl]-2-oxoindol-3-ylidene]amino]-2-(4-nitrophenoxy)acetamide结构式

N-[(E)-[1-[[4-(...

六氢吡啶结构式

甲醛结构式

N'-(5-methyl-2-oxoindolin-3-ylidene)-2-(4-nitrophenoxy)acetohydrazide结构式

N'-(5-methyl-2-...

~65%

N-[[5-methyl-2-oxo-1-(piperidin-1-ylmethyl)indol-3-ylidene]amino]-2-(4-nitrophenoxy)acetamide结构式

N-[[5-methyl-2-...

5-甲基靛红结构式

~%

N-[[5-methyl-2-oxo-1-(piperidin-1-ylmethyl)indol-3-ylidene]amino]-2-(4-nitrophenoxy)acetamide结构式

N-[[5-methyl-2-...

4-硝基苯氧基乙酸肼结构式

4-硝基苯氧基乙酸肼

~%

N-[[5-methyl-2-oxo-1-(piperidin-1-ylmethyl)indol-3-ylidene]amino]-2-(4-nitrophenoxy)acetamide结构式

N-[[5-methyl-2-...

甲醛结构式

甲基苯基哌嗪结构式

甲基苯基哌嗪

N'-(5-methyl-2-oxoindolin-3-ylidene)-2-(4-nitrophenoxy)acetohydrazide结构式

N'-(5-methyl-2-...

~72%

N-[[5-methyl-1-[[4-(4-methylphenyl)piperazin-1-yl]methyl]-2-oxoindol-3-ylidene]amino]-2-(4-nitrophenoxy)acetamide结构式

N-[[5-methyl-1-...

5-甲基靛红结构式

~%

N-[[5-methyl-1-[[4-(4-methylphenyl)piperazin-1-yl]methyl]-2-oxoindol-3-ylidene]amino]-2-(4-nitrophenoxy)acetamide结构式

N-[[5-methyl-1-...

4-硝基苯氧基乙酸肼结构式

4-硝基苯氧基乙酸肼

~%

N-[[5-methyl-1-[[4-(4-methylphenyl)piperazin-1-yl]methyl]-2-oxoindol-3-ylidene]amino]-2-(4-nitrophenoxy)acetamide结构式

N-[[5-methyl-1-...