Synthesis of the acridone alkaloids, glyfoline and congeners. Structure-activity relationship studies of cytotoxic acridones

…, TC Chou, MW Chun, KA Watanabe

文献索引：Su; Kohler; Chou; Moon Woo Chun; Watanabe Journal of Medicinal Chemistry, 1992 , vol. 35, # 14 p. 2703 - 2710

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被引用次数: 39

摘要

Glyfoline (4, 1, 6-dihydroxy-l0-methyl-2, 3, 4, 5-tetramethoxyacridin-9-one) and ita congeners were synthesized for evaluation of their cytotoxicity. A detailed structureactivity relationshipa (SAR) of theae acridone derivatives were also studied. To study the SAR of glyfoline analogum, substituent (8) at C-1 and C-6 and at the heterocyclic nitrogen of glyfoline nucleus were modified. Nitre and amino-substituted glyfoline analogues were ...