Synthesis and DNA binding of [3-[2'-(2-acetamidoethyl)-2, 4'-bithiazole-4-carboxamido] propyl] dimethylsulfonium chloride, a fragment of bleomycin A2

…, JM Riordan, TE Booth, JD Glickson

文献索引：Sakai; Riordan; Booth; Glickson Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 279 - 285

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被引用次数: 38

摘要

[3-[2'-(2-Acetamidoethyl)-2, 4'-bithiazole-4-carboxamido] propyl] dimethylsulfonium chloride (l), the acetyl derivative of the cationic terminal dipeptide of bleomycin A2, has been synthesized and its binding to DNA and poly (dA-dT) has been studied by proton NMR and fluorescence spectroscopy. The spectral perturbations which occur upon binding of the compound to either nucleic acid indicate that that portion of bleomycin which binds to the ...