Journal of medicinal chemistry

Central nervous system depressants. VII. 1 pyridyl coumarins

RB Moffett

文献索引：Moffett,R.B. Journal of Medicinal Chemistry, 1964 , vol. 7, p. 446 - 449

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被引用次数: 69

摘要

Method D. 6-Chloro-3-(4-pyridyl) coumarin (3).-A solution of 37.3 g.(0.24 mole) of 5-chloro~ alicylaldehyde~ 30.2 g.(0.2 mole) of methyl 4-pyridylacetate, and 11.6 ml. of piperidine in 250 ml. of absolute ethanol was heated under reflux with stirring for 2 hr. After about the first 5 min. of heating a solid separated. After cooling the solid was collected, washed dh ethanol, and dried, giving 47.9 g. of solid, mp 268.5-271.5'. This was recrystallized from 350 ml. of ...