Journal of medicinal chemistry

Chemical differentiating agents. Differentiation of HL-60 cells by hexamethylenebis [acetamide] analogs

A Haces, TR Breitman, JS Driscoll

文献索引：Haces, Alberto; Breitman, Theodore B. R.; Driscoll, John S. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 405 - 409

全文：HTML全文

被引用次数: 19

摘要

Hexamethylenebis [acetamide](HMBA) is an agent in clinical trial that induces differentiation of certain types of tumor cells to nonmalignant phenotypes. In an attempt to discover a more potent compound, a number of bisfunctionalized amides, imides, and hydrazine derivatives of HMBA were prepared and evaluated in vitro with the HL-60 human promyelocytic leukemia cell line. Among the compounds evaluated, the 5, 5-dimethylhydantoin ...