Journal of Heterocyclic Chemistry

On the reaction of 2??aminopyridines with alpha??halocarbonyl compounds

AJ Elliott, H Guzik, JR Soler

文献索引：Elliott, Arthur J.; Guzik, Henry; Soler, Jose R. Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1437 - 1440

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被引用次数: 20

摘要

Abstract The reactions of 6-substituted-2-aminopyridines with bromoacetone and 3-bromo-2- butanone have been investigated. In contrast to bromoacetone which gives a high yield of the imidazo [1, 2-a] pyridine, bromobutanone also produces significant amounts of material derived from substitution on the exocyclic nitrogen atom. These adducts, which are not a source of imidazopyridine in the reaction mixture, may be isolated and cyclised under ...