Dibenz [b, c] oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 4. Synthesis and evaluation of 4-(4, 10-dihydro-10-oxothieno [3, 2-c][1] benzoxepin-8-yl) …

…, LL Setescak, TC Spaulding, GC Helsley

文献索引：Martin, Lawrence L.; Setescak, Linda L.; Spaulding, Theodore C.; Helsley, Grover C. Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 372 - 376

全文：HTML全文

被引用次数: 6

摘要

4, 10-Dihydro-10-oxothieno [3, 2-c][l] benzoxepin-8-acetic acid (6) was previously reported as a potent antiinflammatory-analgesic agent characterized by an impressive therapeutic ratio in comparison with indomethacin. With the goal of finding compounds that might display even more favorable therapeutic ratios and/or enhanced antiinflammatory/analgesic properties in comparison to 6, we synthesized 4-(4, 10-dihydro-10-oxothieno [3, 2-c][1]- ...