Journal of the American Chemical Society

The Barbier synthesis: a one-slip Grignard reaction?

G Molle, P Bauer

文献索引：Molle, Gerard; Bauer, Pierre Journal of the American Chemical Society, 1982 , vol. 104, # 12 p. 3481 - 3487

被引用次数: 54

摘要

Abstract: Counter to generally accepted theory, it is demonstrated that the Barbier synthesis does not necessarily involve the in situ formation of an organometallic compound. In certain cases, there is a radical pathway in which the anion radical (RX-) resulting from the attack by a halogenated derivative on lithium is directly trapped by the ketone or by the ketyl radical on the metal surface before the organometallic compound forms. This pathway can be ...