This research addresses the use of an emerging plasma spray technique known as SPPS (Solution Precursor Plasma Spraying) to obtain bioactive glass coatings. In SPPS, the feedstock is a sol precursor of the bioactive glass instead of glass particles. Precursor feedstock composition (presence or not of acid catalyst), plasma torch enthalpy and stand-off distance of the spraying process have been varied to produce bioactive glass coatings of nominally 45S5 composition. A good quality coating was obtained when catalyst (0.2 M acid nitric) was used in the precursor and the plasma spraying took place with shorter stand-off distance and higher plasma enthalpy. Bioactivity in Simulated Body Fluid test was confirmed and an effect of the coating interconnected porosity to enhance bioactivity was observed.