Mild C H Halogenation of Anilides and the Isolation of an Unusual Palladium (I)–Palladium (II) Species

RB Bedford, MF Haddow, CJ Mitchell…

文献索引：Bedford, Robin B.; Haddow, Mairi F.; Mitchell, Charlotte J.; Webster, Ruth L. Angewandte Chemie - International Edition, 2011 , vol. 50, # 24 p. 5524 - 5527

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被引用次数: 111

摘要

Palladium-catalyzed CÀH functionalization/halogenation is a particularly useful method for producing halogenated aromatic products with selectivity that would not ordinarily be obtained under simple electrophilic halogenation conditions (Scheme 1).[1] A significant advance in this area was reported by Shi and co-workers who demonstrated that anilides could be ortho chlorinated in good to excellent yields using Pd-(OAc) 2 as the catalyst and ...