Reaction of 2??acetamido??3, 7??dihydropyrrolo [2, 3??d] pyrimidin??4??one with dimethylamine and formaldehyde. Formation of two isomeric mannich bases
E Benghiat, PA Crooks
文献索引：Benghiat, Eric; Crooks, Peter A. Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1023 - 1025
Abstract 2-Acetamido-3, 7-dihydropyrrolo [2, 3-d) pyrimidin-4-one reacts with dimethylamine and formaldehyde in glacial acetic acid to afford the two isomeric Mannich products, 2- acetamido-3, 7-dihydro-5-dimethylamino-methylpyrrolo [2, 3-d] pyrimidin-4-one, and 2- acetamido-3, 7-dihydro-6-dimethylaminomethylpyrrolo [2, 3-d]-pyrimidin-4-one, in a ratio of 3: 1, respectively.
![2-氨基-4-羟基吡咯并[2,3-d]嘧啶结构式](https://image.chemsrc.com/caspic/303/7355-55-7.png)
![(2-acetamido-7H-pyrrolo[2,3-d]pyrimidin-4-yl) acetate结构式](https://image.chemsrc.com/caspic/214/88062-66-2.png)
![N-(4-氧代-1,7-二氢吡咯并[2,3-d]嘧啶-2-基)乙酰胺结构式](https://image.chemsrc.com/caspic/022/62160-25-2.png)
![2-acetamido-3,7-dihydro-6-dimethylaminomethylpyrrolo[2,3-d]pyrimidin-4-one结构式](https://image.chemsrc.com/caspic/138/88062-68-4.png)
![4H-Pyrrolo[2,3-d]pyrimidin-4-one,2-amino-6-[(dimethylamino)methyl]-3,7-dihydro-结构式](https://image.chemsrc.com/caspic/356/62981-83-3.png)