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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Amnesia-reversal activity of a series of N-[(disubstituted-amino) alkyl]-2-oxo-1-pyrrolidineacetamides, including pramiracetam

…, YJ L'Italien, L Zweisler, PH Poschel…

文献索引：Butler; Nordin; L'Italien; Zweisler; Poschel; Marriott Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 684 - 691

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被引用次数: 36

摘要

A series of N-[(dialkylamino) alkyl]-2-oxo-l-pyrrolidineacetamides was synthesized. The title compounds reversed electroconvulsive shock (ECS) induced amnesia in mice when administered subsequent to the ECS treatment and were inactive in a general observational test for central nervous system (CNS) activity. Active compounds exhibited an inverted U- shaped dose-response curve. Among the compounds with the broadest dose-response ...

N-(3-氨丙基)-2-甲基哌啶结构式

N-(3-氨丙基)-2-甲基哌啶

2-(2-氧代吡咯烷-1-基)乙酸乙酯结构式

2-(2-氧代吡咯烷-1-基)乙酸乙酯

~66%

N-[3-(2-methylpiperidin-1-yl)propyl]-2-(2-oxopyrrolidin-1-yl)acetamide结构式

N-[3-(2-methylp...

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2-(2-氧代吡咯烷-1-基)乙酸乙酯结构式

2-(2-氧代吡咯烷-1-基)乙酸乙酯

N,N-diisobutyl-propanediyldiamine结构式

N,N-diisobutyl-...

~54%

N-[3-[bis(2-methylpropyl)amino]propyl]-2-(2-oxopyrrolidin-1-yl)acetamide结构式

N-[3-[bis(2-met...

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二异丁胺结构式

~%

N-[3-[bis(2-methylpropyl)amino]propyl]-2-(2-oxopyrrolidin-1-yl)acetamide结构式

N-[3-[bis(2-met...

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3-[bis(2-methylpropyl)amino]propanenitrile结构式

3-[bis(2-methyl...

~%

N-[3-[bis(2-methylpropyl)amino]propyl]-2-(2-oxopyrrolidin-1-yl)acetamide结构式

N-[3-[bis(2-met...

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2-(2-氧代吡咯烷-1-基)乙酸乙酯结构式

2-(2-氧代吡咯烷-1-基)乙酸乙酯

N,N-Diisopropyl-1,3-propanediamine结构式

N,N-Diisopropyl...

~42%

N-[3-[di(propan-2-yl)amino]propyl]-2-(2-oxopyrrolidin-1-yl)acetamide结构式

N-[3-[di(propan...

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2-(2-氧代吡咯烷-1-基)乙酸乙酯结构式

2-(2-氧代吡咯烷-1-基)乙酸乙酯

N,N'-di(propan-2-yl)butane-1,4-diamine结构式

N,N'-di(propan-...

~65%

N-[4-[di(propan-2-yl)amino]butyl]-2-(2-oxopyrrolidin-1-yl)acetamide结构式

N-[4-[di(propan...

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3-苯基吡咯烷-2-酮结构式

3-苯基吡咯烷-2-酮

溴乙酸乙酯结构式

溴乙酸乙酯

~45%

3-苯基-2-碳基-1-吡咯烷乙酸乙酯结构式

3-苯基-2-碳基-1-吡咯烷乙酸乙酯

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2-(2-氧代吡咯烷-1-基)乙酸乙酯结构式

2-(2-氧代吡咯烷-1-基)乙酸乙酯

N,N-二异丙基乙二胺结构式

N,N-二异丙基乙二胺

~69%

普拉西坦结构式

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1-(2-氨基乙基)哌啶结构式

1-(2-氨基乙基)哌啶

2-(2-氧代吡咯烷-1-基)乙酸乙酯结构式

2-(2-氧代吡咯烷-1-基)乙酸乙酯

~77%

2-(2-oxopyrrolidin-1-yl)-N-(2-piperidin-1-ylethyl)acetamide结构式

2-(2-oxopyrroli...

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2-哌啶-1-丙胺结构式

2-哌啶-1-丙胺

2-(2-氧代吡咯烷-1-基)乙酸乙酯结构式

2-(2-氧代吡咯烷-1-基)乙酸乙酯

~50%

2-(2-oxopyrrolidin-1-yl)-N-(2-piperidin-1-ylpropyl)acetamide结构式

2-(2-oxopyrroli...

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2-(2-氧代吡咯烷-1-基)乙酸乙酯结构式

2-(2-氧代吡咯烷-1-基)乙酸乙酯

N,N-二异丁基乙烯二胺结构式

N,N-二异丁基乙烯二胺

~54%

N-[2-[bis(2-methylpropyl)amino]ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide结构式

N-[2-[bis(2-met...

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1-(2-氨基-1,1-二甲基乙基)哌啶结构式

1-(2-氨基-1,1-二甲基乙基)哌啶

2-(2-氧代吡咯烷-1-基)乙酸乙酯结构式

2-(2-氧代吡咯烷-1-基)乙酸乙酯

~43%

N-(2-methyl-2-piperidin-1-ylpropyl)-2-(2-oxopyrrolidin-1-yl)acetamide结构式

N-(2-methyl-2-p...

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2-Oxo-4-phenyl-1-pyrrolidineacetic Acid Ethyl Ester结构式

2-Oxo-4-phenyl-...

N,N-二乙基乙二胺结构式

N,N-二乙基乙二胺

~27%

N-[2-(diethylamino)ethyl]-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide结构式

N-[2-(diethylam...

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2-(2-氧代吡咯烷-1-基)乙酸乙酯结构式

2-(2-氧代吡咯烷-1-基)乙酸乙酯

3-二甲氨基丙胺结构式

3-二甲氨基丙胺

~70%

N-[3-(dimethylamino)propyl]-2-(2-oxopyrrolidin-1-yl)acetamide结构式

N-[3-(dimethyla...

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2-(2-氧代吡咯烷-1-基)乙酸乙酯结构式

2-(2-氧代吡咯烷-1-基)乙酸乙酯

N,N-二乙基乙二胺结构式

N,N-二乙基乙二胺

~71%

N-[2-(diethylamino)ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide结构式

N-[2-(diethylam...

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2-(2-氧代吡咯烷-1-基)乙酸乙酯结构式

2-(2-氧代吡咯烷-1-基)乙酸乙酯

N,N-二甲基乙二胺结构式

N,N-二甲基乙二胺

~58%

N-[2-(dimethylamino)ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide结构式

N-[2-(dimethyla...

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2-(2-氧代吡咯烷-1-基)乙酸乙酯结构式

2-(2-氧代吡咯烷-1-基)乙酸乙酯

(2-Aminoethyl)(methyl)(propan-2-yl)amine结构式

(2-Aminoethyl)(...

~59%

N-[2-[methyl(propan-2-yl)amino]ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide结构式

N-[2-[methyl(pr...

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2-[methyl(propan-2-yl)amino]acetonitrile结构式

2-[methyl(propa...

~%

N-[2-[methyl(propan-2-yl)amino]ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide结构式

N-[2-[methyl(pr...

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