Synlett 2018-03-28

PPh3-Mediated [3+2] Cycloaddition Reaction between Bis-Substituted Allenoate and N-Tosylaldimines to Construct 2-Pyrrolines

Kong, Xiangwen, Liu, Lihua, Luo, Siqin, Fan, Shilu, Qian, Haisheng, Xiao, Hua

文献索引：10.1055/s-0037-1609489

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摘要

A triphenylphosphine-promoted [3+2] cycloaddition of α,γ-bis-substituted allenoates and N-tosylaldimines followed by alkene isomerization was disclosed, affording a series of functionalized 2-pyrroline derivatives in moderate chemical yields with random diastereoselectivities.