Nickel-catalyzed enantioselective sequential Nazarov cyclization/decarboxylation
Heyi Zhang, Zhan Lu
文献索引：10.1039/C8QO00279G
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摘要
The nickel-catalyzed enantioselective sequential Nazarov cyclization/decarboxylation has been developed. The use of chiral oxazoline iminopyridine and metal perchlorate allows the enantioselective decarboxylative electrocyclization of divinyl ketones bearing an α-ester group to afford chiral cyclopentenones in good yields with excellent enantioselectivities. Various derivatizations could be easily carried out to deliver chiral polysubstituted cyclopentenes. Primary mechanistic studies demonstrated that nickel-catalyzed asymmetric Nazarov cyclization was followed by nickel-promoted decarboxylation.