Organometallics 2018-04-05

Metal Acetylide Elimination: The Key Step in the Cascade Decomposition and Transformation of Metalated Propargylamines

MatthewT. Flynn, Victoria L. Blair, Philip C. Andrews

文献索引：10.1021/acs.organomet.8b00047

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摘要

Metal acetylide elimination facilitates a novel one-pot cascade metalation and elimination/addition route to a series of unsymmetrical secondary amines from the reaction of secondary propargylamines with organometallic reagents. Spectroscopic evidence suggests a dimetalated amido intermediate rather than an allene.