Organic Letters 2018-04-10

Schincalactones A and B, Two 5/5/6/11/3 Fused Schinortriterpenoids with a 13-Membered Carbon Ring System from Schisandra incarnata

Jian Song, Ming Zhou, Jia Zhou, Jing-Jing Liang, Xiao-Gang Peng, Junjun Liu, Han-Li Ruan

文献索引：10.1021/acs.orglett.8b00889

摘要

Two novel schinortriterpenoids (SNTs), schincalactones A (1) and B (2), featuring a unique 5/5/6/11/3 ring system, together with schincalide B (3), were isolated from Schisandra incarnata. Their structures were elucidated by detailed spectroscopic analysis, and the absolute configurations of 1 and 3 were confirmed by single-crystal X-ray diffraction. Compounds 1 and 2 possess a 13-membered carbon ring and are the first examples in the SNT family. Plausible biosynthetic pathways of 1–3 were postulated.