4-Hydroxy-3-quinolinecarboxamides with antiarthritic and analgesic activities

F Clemence, O Le Martret, F Delevallee…

文献索引：Clemence; Le Martret; Delevallee; Benzoni; Jouanen; Jouquey; Mouren; Deraedt Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1453 - 1462

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被引用次数: 108

摘要

A series of 4-hydroxy-3-quinolinecarboxamides has been synthesized and evaluated by the oral route as antiinflammatory agents in carrageenin-induced foot edema and adjuvant- induced arthritis and as analgesic agents in the acetic acid induced writhing test. Among the most active molecules, some have shown both analgesic and acute antiinflammatory activities. Others, such as compounds 24, 37, and 52, were only powerful peripherally ...