Bioorganic & medicinal chemistry letters

Synthesis and evaluation of novel aromatic substrates and competitive inhibitors of GABA aminotransferase

MD Clift, RB Silverman

文献索引：Clift, Michael D.; Silverman, Richard B. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 10 p. 3122 - 3125

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被引用次数: 13

摘要

The design, synthesis, and evaluation of novel γ-aminobutyric acid aminotransferase (GABA- AT) inhibitors and inactivators can lead to the discovery of new GABA-related therapeutics. To this end, a series of aromatic amino acid compounds was synthesized to aid in the design of new inhibitors and inactivators of GABA-AT. All compounds were tested as competitive inhibitors of GABA-AT. The amino acids with benzylic amines were also tested ...