Yi Li, Quang Nam Bui, Le Thai Minh Duy, Hong Yu Yang, Doo Sung Lee
文献索引:10.1021/acs.biomac.8b00195
全文:HTML全文
In this work, pH-responsive polypeptide-based nanogels are reported as potential drug delivery systems. By the formation of pH-sensitive benzoic imine bonds, pH-responsive nanogels are constructed using hydrophilic methoxy poly(ethylene glycol)-b-poly[N-[N-(2-aminoethyl)-2-aminoethyl]-l-glutamate] (MPEG-b-PNLG) and hydrophobic terephthalaldehyde (TPA) as a cross-linker. At pH 7.4, MPEG-b-PNLG nanogels exhibit high stabilities with hydrophobic inner cores, which allow encapsulation of hydrophobic therapeutic agents. Under tumoral acidic environments (pH ∼6.4), the cleavage of benzoic imine bonds induces the destruction of MPEG-b-PNLG nanogels and leads to rapid release of their payloads. The formation and pH sensitivity of the nanogels are investigated by dynamic light scattering. These nanogels exhibit excellent stabilities in the presence of salt or against dilution. The globular morphologies of the nanogels are confirmed using transmission electron microscopy. Doxorubicin is used as a model drug to evaluate drug encapsulation and release. Finally, the anticancer activities of the drug-encapsulated nanogels are assessed in vitro.
3D Protein-Based Bilayer Artificial Skin for the Guided Scar...
2018-04-18 [10.1021/acs.biomac.7b01807] |
A Dual-Targeting Delivery System for Effective Genome Editin...
2018-04-16 [10.1021/acs.biomac.8b00511] |
Salt- and pH-Triggered Helix–Coil Transition of Ionic Polype...
2018-04-16 [10.1021/acs.biomac.8b00204] |
Allosteric Control of Peroxidase-Mimicking DNAzyme Activity ...
2018-04-13 [10.1021/acs.biomac.8b00201] |
Photo- and Reduction-Responsive Polymersomes for Programmed ...
2018-04-12 [10.1021/acs.biomac.8b00253] |
首页 |
期刊大全 |
MSDS查询 |
化工产品分类 |
生物活性化合物 |
关于我们 |
免责声明:知识产权问题请联系 service1@chemsrc.com
Copyright © 2024 ChemSrc All Rights Reserved