One-stage procedure of synthesis of highly reactive α-chloro-β-ketoacetals. 4-chloropyrazoles from α-chloro-β-ketodimethoxyacetals

…, VA Savosik, AN Mirskova, GG Levkovskaya

文献索引：Bozhenkov; Savosik; Mirskova; Levkovskaya Russian Journal of Organic Chemistry, 2008 , vol. 44, # 2 p. 184 - 189

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被引用次数: 2

摘要

Abstract Conditions were developed where the reaction of alkyl 1, 2-dichlorovinyl ketones with alcohols and 1, 2-dihydroxybenzenes led to the formation of the corresponding open- chain and cyclic α-chloro-β-ketoacetals. The reaction of α-chloro-β- alkylketodimethoxyacetals with alkyl-, benzyl-, and arylhydrazines resulted in 1, 3- substituted 4-chloropyrazoles in 70–90% yields demonstrating that primarily formed 2, 2- ...