Synthesis and antitumor activity of 1-substituted-2-methyl-5-nitrobenzimidazoles

…, MA Omar, AMM El-Khamry, HI El-Diwani

文献索引：Ramla, Mostafa M.; Omar, Mohamed A.; El-Khamry, Abdel-Momen M.; El-Diwani, Hoda I. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 21 p. 7324 - 7332

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被引用次数: 103

摘要

Different substituents were introduced in position 1 of 2-methyl-5 (6)-nitro-1H-benzimidazole (2) in order to obtain different side chains having different heterocyclic compounds, for example, thiadiazoles (5–7), tetrazoles (8, 9a, b), triazoles (11–13), thiazoles (14a–e), triazines (10, 16, 17), and imidazoles (18a–c). The antitumor effect of compounds 1, 2, 2a, 4, 5, 7, 8, 9a, 10, 13, 14a, 15, 16, and 18c was studied against breast cancer (MCF7) and ...