I I1 are difficult to alkylate it has been reported that nitromethane is a better choice of~ olvent.~ When the ring nitrogen is hindered sterically, alkylation is very difficult and in the case of quinoline-2-aldoxime it was U~ SUCC~ SS~ U~.~~ In the case where a methyl group at the 6-position of picolinaldehyde oxime hinders the ring nitrogen sterically, it was shown that alkylation occurs on the nitrogen of the oxime rather than on the ring. 6
