Development of a Scalable Route to a Dual NK-1/Serotonin Receptor Antagonist

C Risatti, KJ Natalie Jr, Z Shi…

文献索引：Xu, Yuelian; Han, Bingsong; Wang, Zhe-Qing; Shaw, Kenneth R.; Chenard, Bertrand L.; Maynard, George; Xie, Linghong Organic Process Research and Development, 2007 , vol. 11, # 4 p. 716 - 720

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被引用次数: 14

摘要

... either citric acid or Rochelle's salts produced emulsions and low yields, the procedure described by ... potassium phosphate (K 3 PO 4 ) and azeotropic drying, the rich organic stream was ... figure Scheme 7. Final process for preparation of 1·HCl. Conclusions A highly efficient route ...