Flavins as potential antimalarials. 2. 3-Methyl-10-(substituted-phenyl) flavins

…, PK Halladay, RB Cunningham, NH Hunt…

文献索引：Cowden; Halladay; Cunningham; Hunt; Clark Journal of Medicinal Chemistry, 1991 , vol. 34, # 6 p. 1818 - 1822

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被引用次数: 15

摘要

3 5 R= NOp stitution, respectively, in benzene rings. Spin decoupling experiments, in which all doublets and multiplets were decoupled, confirmed this assignment. 4'-Hydroxy analogue 2p was prepared both by the method described above and by cleaving the ether linkage of the 4 '-methoxy derivative 21 with HBr in acetic acid. 4'-Carboxylate 2dd (Table 11) was prepared in good yield by acid-catalyzed hydrolysis of the corresponding nitrile (2q; Table ...