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Design, synthesis, antimicrobial activity and anti-HIV activity evaluation of novel hybrid quinazoline–triazine derivatives

RP Modh, E De Clercq, C Pannecouque…

文献索引:Modh, Rahul P.; De Clercq, Erik; Pannecouque, Christophe; Chikhalia, Kishor H. Journal of Enzyme Inhibition and Medicinal Chemistry, 2014 , vol. 29, # 1 p. 100 - 108

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被引用次数: 10

摘要

Abstract A series of novel hybrid quinazoline–triazine derivatives was designed and synthesized from cyanuric chloride and anthranilic acid through sequential reactions, which contain different pharmacophores like quinazoline and substituted diaryl triazine (DATA) linked with ethylene diamine. All the newly synthesized compounds were characterized by infrared, 1H-NMR, 13C-NMR, MS and elemental analysis. Further, we evaluated the in ...