Synthesis and aldose reductase inhibitory activity of N-(quinolinyl thiocarbonyl) glycine derivatives

…, T Güngör, J Goyard, G Cure, A Fouquet…

文献索引：Nicolaie, E; Guengoer, T; Goyard, J; Cure, G; Fouquet, A; et al. European Journal of Medicinal Chemistry, 1992 , vol. 27, # 9 p. 977 - 984

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被引用次数: 5

摘要

Abstract The onset of diabetic complications may be prevented by the inhibition of aldose reductase. Derivatives of N-(quinolinyl thiocarbonyl) glycine were prepared and their in vitro and ex vivo aldose reductase inhibitory activities were tested on rat lens. The cincophen derivatives were the most potent in vitro with an enzyme inhibition value of 29% at 10− 8 M and 91% at 10− 7 M for the N-[(2-phenylquinolin-4-yl) thiocarbonyl]-N-methylglycine ...