Anti-mutagenic structural modification by fluorine-substitution in highly mutagenic 4-methylquinoline derivatives

T Kato, A Hakura, T Mizutani, K Saeki

文献索引：Kato, Taka-Aki; Hakura, Atsushi; Mizutani, Takaharu; Saeki, Ken-Ichi Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2000 , vol. 465, # 1-2 p. 173 - 182

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被引用次数: 19

摘要

We have previously shown that fluorine-substitution at position 3 of quinoline deprived this molecule of mutagenicity, possibly due to interference with the yield of its metabolically activated form, the 1, 4-hydrated 2, 3-epoxide (enamine epoxide), which is directly responsible for the mutagenic modification of DNA. To further explore the possibility of a method for anti-mutagenic modification of mutagens by fluorine-substitution, 4- ...