Substituted 1, 2, 3, 4-tetrahydroaminonaphthols: antihypertensive agents, calcium channel blockers, and adrenergic receptor blockers with catecholamine-depleting …

…, BC O'Reilly, EP Ruby, CF Turk, G Aberg…

文献索引：Atwal, Karnail S.; O'Reilly, Brian C.; Ruby, Eric P.; Turk, Chester F.; Aberg, Gunnar; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 627 - 635

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被引用次数: 25

摘要

Substituted 1, 2, 3, 4-tetrahydroaminonaphthols were found to be calcium channel blockers with antihypertensive properties. These compounds also possessed adrenergic P-receptor blocking activity. From the structure-activity studies, no clear correlation emerged between the in vitro calcium channel blocking activity and the acute antihypertensive activity in cannulated spontaneously hypertensive rats. Extensive pharmacological testing of ...