The Journal of organic chemistry

Cobalt-catalyzed reductive coupling of saturated alkyl halides with activated alkenes

P Shukla, YC Hsu, CH Cheng

文献索引：Shukla, Paritosh; Hsu, Yun-Chu; Cheng, Chien-Hong Journal of Organic Chemistry, 2006 , vol. 71, # 2 p. 655 - 658

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被引用次数: 47

摘要

An efficient cobalt-catalyzed reductive coupling reaction of alkyl halides with electron- withdrawing alkenes (CH2 CR1EWG, EWG= electron-withdrawing group) in the presence of water and zinc powder in acetonitrile to give the corresponding Michael-type addition product (RCH2CR1EWG) was described. The methodology is versatile such that unactivated primary, secondary, and tertiary alkyl bromides and iodides and various ...