Synthesis and inhibitory activities against colon cancer cell growth and proteasome of alkylresorcinols

Y Zhu, DN Soroka, S Sang

文献索引：Zhu, Yingdong; Soroka, Dominique N.; Sang, Shengmin Journal of Agricultural and Food Chemistry, 2012 , vol. 60, # 35 p. 8624 - 8631

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被引用次数: 10

摘要

We have identified alkylresorcinols (ARs) as the major active components in wheat bran against human colon cancer cell growth (HCT-116 and HT-29) using a bioassay-guided approach. To further study the structure–activity relationships, 15 ARs and their intermediates (1–15) were synthesized expediently by the modified Wittig reaction in aqueous media, and six 5-alkylpyrogallols and their analogues (16–21) were prepared by ...