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Efficient synthesis of aryl hydroxylactams by reducing imides with activated zinc dust

X Yuan, M Zhang, C Kang, H Guo, X Qiu…

文献索引:Yuan, Xiu-Hua; Zhang, Min-Jie; Kang, Chuan-Qing; Guo, Hai-Quan; Qiu, Xue-Peng; Gao, Lian-Xun Synthetic Communications, 2006 , vol. 36, # 4 p. 435 - 444

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被引用次数: 5

摘要

Abstract A series of aryl hydroxylactams (2a, 2b, 2d–2g, 2i–2k, 2m, and 2n) was synthesized by partially reducing aryl cyclic imides in moderate to excellent yields with activated zinc dust alone in acetic acid. This method was regiospecific and can be employed as an alternative for reported methods to partially reduce aryl cyclic imides.