ZINClick: a database of 16 million novel, patentable, and readily synthesizable 1, 4-disubstituted triazoles

A Massarotti, A Brunco, G Sorba…

文献索引：Massarotti, Alberto; Brunco, Angelo; Sorba, Giovanni; Tron, Gian Cesare Journal of Chemical Information and Modeling, 2014 , vol. 54, # 2 p. 396 - 406

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被引用次数: 5

摘要

Since Professors Sharpless, Finn, and Kolb first introduced the concept of “click reactions” in 2001 as powerful tools in drug discovery, 1, 4-disubstituted-1, 2, 3-triazoles have become important in medicinal chemistry due to the simultaneous discovery by Sharpless, Fokin, and Meldal of a perfect click 1, 3-dipolar cycloaddition reaction between azides and alkynes catalyzed by copper salts. Because of their chemical features, these triazoles are ...