RSC Advances

Phenyl hydrazone bearing pyrazole and pyrimidine scaffolds: design and discovery of a novel class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) …

…, A Verma, MK Kumawat, R Kaur, SK Gupta, RK Singh

文献索引：Singh, Udaya Pratap; Bhat, Hans Raj; Verma, Amita; Kumawat, Mukesh Kumar; Kaur, Rajinder; Gupta; Singh, Ramendra K. RSC Advances, 2013 , vol. 3, # 38 p. 17335 - 17348

全文：HTML全文

被引用次数: 4

摘要

A novel series of phenyl hydrazone bearing pyrazole and pyrimidine hybrid compounds has been designed using the molinspiration toolkit based on Lipinski's rule of five and developed via sequential reactions starting from the diazotization of different anilines and further active methylation with acetyl acetone, ethyl acetoacetate and ethyl cyanoacetate to generate hydrazono derivatives. The target hybrid compounds were synthesized on ...