Synthesis and biological evaluation of analogues of the anti-tumor alkaloid naamidine A

N Aberle, J Catimel, EC Nice, KG Watson

文献索引：Aberle, Nicholas; Catimel, Jenny; Nice, Edouard C.; Watson, Keith G. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3741 - 3744

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被引用次数: 27

摘要

A small series of derivatives of the alkaloid naamidine A was synthesized and tested in vitro for their ability to inhibit mitogenesis in BaF/ERX cells. Replacement of the imidazole core with a thiazole was found to have only a minor effect on potency, and the 4-methoxybenzyl substituent of the natural product was shown to be unnecessary for activity.